Machine Learning Claude Skills
1 780 machine learning skills from 282 authors. They train and fine-tune models, build embeddings, run RAG and measure quality. Half of them fit into 2 252 tokens or less — that is what one costs your context window when the agent loads it. 424 ship runnable scripts rather than instructions alone. 10 of them cannot work without an MCP server, most often rube. We also found 397 copies of these same skills sitting in other people's repositories — counted once here, not 397 times.
1 780 unique 282 authors 5 updated this month 189 from vendors
Retrieval-augmented generation (RAG) skill for the D&D 5e System Reference Document (SRD). Use when answering questions about D&D 5e core rules, spells, combat, equipment, conditions, monsters, and other SRD content. This skill provides agentic search-based access to the SRD split into page-range markdown files.
Implement ReasoningBank adaptive learning with AgentDB's 150x faster vector database. Includes trajectory tracking, verdict judgment, memory distillation, and pattern recognition. Use when building self-learning agents, optimizing decision-making, or implementing experience replay systems.
Achieve aggressive v3 performance targets: 2.49x-7.47x Flash Attention speedup, 150x-12,500x search improvements, 50-75% memory reduction. Comprehensive benchmarking and optimization suite.
Implements document chunking, embedding generation, vector storage, and retrieval pipelines for Retrieval-Augmented Generation systems. Use when building RAG applications, creating document Q&A systems, or integrating AI with knowledge bases.
Provides AWS CloudFormation patterns for Amazon Bedrock resources including agents, knowledge bases, data sources, guardrails, prompts, flows, and inference profiles. Use when creating Bedrock agents with action groups, implementing RAG with knowledge bases, configuring vector stores, setting up content moderation guardrails, managing prompts, orchestrating workflows with flows, and configuring inference profiles for model optimization.
Provides chunking strategies for RAG systems. Generates chunk size recommendations (256-1024 tokens), overlap percentages (10-20%), and semantic boundary detection methods. Validates semantic coherence and evaluates retrieval precision/recall metrics. Use when building retrieval-augmented generation systems, vector databases, or processing large documents.
Provides Amazon Bedrock patterns using AWS SDK for Java 2.x. Invokes foundation models (Claude, Llama, Titan), generates text and images, creates embeddings for RAG, streams real-time responses, and configures Spring Boot integration. Use when asking about Bedrock integration, Java SDK for AI models, AWS generative AI, Claude/Llama invocation, embeddings for RAG, or Spring Boot AI setup.
Provides patterns to build declarative AI Services with LangChain4j for LLM integration, chatbot development, AI agent implementation, and conversational AI in Java. Generates type-safe AI services using interface-based patterns, annotations, memory management, and tools integration. Use when creating AI-powered Java applications with minimal boilerplate, implementing conversational AI with memory, or building AI agents with function calling.
Provides Retrieval-Augmented Generation (RAG) implementation patterns with LangChain4j for Java. Generates document ingestion pipelines, embedding stores, vector search, and semantic search capabilities. Use when building chat-with-documents systems, document Q&A over PDFs or text files, AI assistants with knowledge bases, semantic search over document repositories, or knowledge-enhanced AI applications with source attribution.
Provides integration patterns for LangChain4j with Spring Boot. Configures AI model beans, sets up chat memory with Spring context, integrates RAG pipelines with Spring Data, and handles auto-configuration, dependency injection, and Spring ecosystem integration. Use when embedding LangChain4j into Spring Boot applications, building Java LLM applications with @Bean configuration, or setting up Spring AI patterns.
Provides configuration patterns for LangChain4J vector stores in RAG applications. Use when building semantic search, integrating vector databases (PostgreSQL/pgvector, Pinecone, MongoDB, Milvus, Neo4j), implementing embedding storage/retrieval, setting up hybrid search, or optimizing vector database performance for production AI applications.
Provides Qdrant vector database integration patterns with LangChain4j. Handles embedding storage, similarity search, and vector management for Java applications. Use when implementing vector-based retrieval for RAG systems, semantic search, or recommendation engines.
Enables interaction with Google NotebookLM for advanced RAG (Retrieval-Augmented Generation) capabilities via the notebooklm-mcp-cli tool. Use when querying project documentation stored in NotebookLM, managing research notebooks and sources, retrieving AI-synthesized information, generating audio podcasts or reports from notebooks, or performing contextual queries against curated knowledge bases. Triggers on "notebooklm", "nlm", "notebook query", "research notebook", "query documentation in notebooklm".
Stop and consult this skill whenever your response would include specific facts about Anthropic's products. Covers: Claude Code (how to install, Node.js requirements, platform/OS support, MCP server integration, configuration), Claude API (function calling/tool use, batch processing, SDK usage, rate limits, pricing, models, streaming), and Claude.ai (Pro vs Team vs Enterprise plans, feature limits). Trigger this even for coding tasks that use the Anthropic SDK, content creation mentioning Claude capabilities or pricing, or LLM provider comparisons. Any time you would otherwise rely on memory for Anthropic product details, verify here instead — your training data may be outdated or wrong.
Compile NYC landmarks, DOB, ACRIS, HPD, and BSA findings into one property due-diligence report. Use for a full report; use individual NYC skills for one dataset.
Python library for genomic interval ML. Train/apply region2vec embeddings turning BED regions into vectors, index interval datasets for ML, search embedding space with BEDSpace, and evaluate embedding quality. Use for chromatin accessibility clustering, regulatory element classification, and cross-sample region comparison.
Query CELLxGENE Census (61M+ cells). Search by cell type/tissue/disease/organism; get AnnData, stream out-of-core, train PyTorch models. For your own data use scanpy; for annotated data use anndata.
Query and download NCI Imaging Data Commons (IDC) cancer radiology and pathology datasets via the idc-index Python client. No authentication required: the parquet index ships inside the pip wheel, SQL runs locally via DuckDB, and DICOM downloads stream from public S3/GCS buckets through s5cmd. Use sql_query() for DuckDB cohort selection, get_collections/get_patients/get_dicom_studies/get_dicom_series for hierarchical browsing, download_from_selection() for downloads, and get_viewer_URL() for OHIF/Slim links. Use pydicom-medical-imaging for local DICOM reading; histolab for whole-slide pathology preprocessing.
Computational pathology toolkit for whole-slide images (WSIs): load slides, extract tiles, stain normalization, nuclear segmentation, feature extraction, and ML training. Supports H&E and multiplex. For end-to-end pipelines from raw WSIs to quantitative outputs.
Protein language models (ESM3, ESM C) for sequence generation, structure prediction, inverse folding, and embeddings. Design novel proteins, extract ML features, or fold sequences. Local GPU or EvolutionaryScale Forge API. Use AlphaFold for traditional folding; RDKit for small molecules.
Python library for healthcare ML on EHR data: process MIMIC-III/IV, eICU, OMOP-CDM; encode medical codes (ICD, ATC, NDC); build patient-level datasets; train Transformer, RETAIN, GRASP, MedBERT for mortality, drug recommendation, readmission, diagnosis prediction. Alternatives: FIDDLE (preprocessing), clinical-longformer (clinical NLP), ehr-ml (embeddings).
Structured hypothesis formulation: turn observations into testable hypotheses with predictions, propose mechanisms, design experiments. Follows the scientific method. Use scientific-brainstorming for open ideation; hypogenic for automated LLM hypothesis testing on datasets.
Deep learning for drug discovery. 60+ models (GCN, GAT, AttentiveFP, MPNN, ChemBERTa, GROVER), 50+ featurizers, MoleculeNet benchmarks, HPO, transfer learning. Unified load-featurize-split-train-evaluate API. For fingerprints use rdkit-cheminformatics; for featurization-only use molfeat.
Diffusion-based docking that predicts protein-ligand poses without a predefined site. Use for blind docking, when traditional docking fails, or exploring multiple binding modes. Pipeline: prep protein (PDB) and ligand (SMILES/SDF), run inference, analyze confidence-ranked poses.
Molecular featurization hub (100+ featurizers) for ML. SMILES to fingerprints (ECFP, MACCS, MAP4), descriptors (RDKit 2D, Mordred), pretrained embeddings (ChemBERTa, GIN, Graphormer), pharmacophores. Scikit-learn compatible with parallelization/caching. For QSAR, virtual screening, similarity, and molecular DL.
PyTorch-based ML platform for drug discovery: graph molecular representation learning, property prediction (ADMET, activity), retrosynthesis, drug-target interaction (DTI), and pretraining on large molecular datasets. Provides GNN layers (GraphConv, GAT, MPNN), pretrained models, and benchmark datasets.
Open-source FAIR biology data framework. Version artifacts (AnnData, DataFrame, Zarr), track lineage, validate via ontologies (Bionty), query datasets. Integrates with Nextflow, Snakemake, W&B, scVI. For scRNA-seq use scanpy; for ontology lookups use bionty.
Use for Kaggle competition overview fetches, writeups, discussion/kernel research, submissions, and dataset uploads. Not for unrelated ML code.
Use up-to-date library and framework docs via Context7 MCP instead of training data. Activates for setup questions, API references, code examples, or when the user names a framework (e.g. React, Next.js, Prisma).
Cost optimization patterns for LLM API usage — model routing by task complexity, budget tracking, retry logic, and prompt caching.
Neural search via Exa MCP for web, code, and company research. Use when the user needs web search, code examples, company intel, people lookup, or AI-powered deep research with Exa's neural search engine.
PyTorch deep learning patterns and best practices for building robust, efficient, and reproducible training pipelines, model architectures, and data loading.
Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.
Use up-to-date library and framework docs via Context7 MCP instead of training data. Activates for setup questions, API references, code examples, or when the user names a framework (e.g. React, Next.js, Prisma).
Neural search via Exa MCP for web, code, and company research. Use when the user needs web search, code examples, company intel, people lookup, or AI-powered deep research with Exa's neural search engine.
PyTorch deep learning patterns and best practices for building robust, efficient, and reproducible training pipelines, model architectures, and data loading.
Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.
Cost optimization patterns for LLM API usage — model routing by task complexity, budget tracking, retry logic, and prompt caching.
Use up-to-date library and framework docs via Context7 MCP instead of training data. Activates for setup questions, API references, code examples, or when the user names a framework (e.g. React, Next.js, Prisma).
Neural search via Exa MCP for web, code, and company research. Use when the user needs web search, code examples, company intel, people lookup, or AI-powered deep research with Exa's neural search engine.
PyTorch deep learning patterns and best practices for building robust, efficient, and reproducible training pipelines, model architectures, and data loading.
Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.
Cost optimization patterns for LLM API usage — model routing by task complexity, budget tracking, retry logic, and prompt caching.
Use up-to-date library and framework docs via Context7 MCP instead of training data. Activates for setup questions, API references, code examples, or when the user names a framework (e.g. React, Next.js, Prisma).
Neural search via Exa MCP for web, code, and company research. Use when the user needs web search, code examples, company intel, people lookup, or AI-powered deep research with Exa's neural search engine.
PyTorch deep learning patterns and best practices for building robust, efficient, and reproducible training pipelines, model architectures, and data loading.
Decision framework for choosing between regex and LLM when parsing structured text — start with regex, add LLM only for low-confidence edge cases.
作为代理工程师，采用评估优先执行、分解和成本感知模型路由进行操作。