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Interpro MCP Server

local only

Interpro MCP runs on your own machine — the client starts it, so there is no endpoint to ping. 122 installs a week from npm. Last commit 8 Nov 2026.

InterPro protein families and domains: search entries and find the domains in one protein - keyless.

Installs per day peak 367 · avg 28 · -83% w/w
a month agotoday
122
Installs / week
npm · @mrfentmen/interpro-mcp
0
Stars
0 open issues
8 Nov 2026
Last commit
4 releases in 90 days
—
License
TypeScript

Nothing serious here today

Today is the operative word: we check Interpro MCP every 15 minutes and re-read its code on every release. Watch it and you find out the day that stops being true.

Three servers free · no card

Connect this server

This server runs on your own machine — install it with the package manager and the client starts it for you. Package name taken from the official registry entry.

run in your terminal
claude mcp add interpro-mcp -- npx -y @mrfentmen/interpro-mcp
~/Library/Application Support/Claude/claude_desktop_config.json
{
  "mcpServers": {
    "interpro-mcp": {
      "command": "npx",
      "args": [
        "-y",
        "@mrfentmen/interpro-mcp"
      ]
    }
  }
}
~/.codex/config.toml
[mcp_servers.interpro-mcp]
command = "npx"
args = ["-y", "@mrfentmen/interpro-mcp"]
.cursor/mcp.json
{
  "mcpServers": {
    "interpro-mcp": {
      "command": "npx",
      "args": [
        "-y",
        "@mrfentmen/interpro-mcp"
      ]
    }
  }
}
.vscode/mcp.json
{
  "servers": {
    "interpro-mcp": {
      "type": "stdio",
      "command": "npx",
      "args": [
        "-y",
        "@mrfentmen/interpro-mcp"
      ]
    }
  }
}

Alternatives to Interpro MCP

same job, measured the same way
Interpro MCP Server
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Search InterPro entries, map domains onto proteins and PDB structures, and scan raw sequences.

130 installs/wk 9 tools answering
Kegg MCP
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Interpro
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DoableClaw Research
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AI research on companies and industries — one MCP tool per research domain.

answering
Hpo MCP
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Search HPO phenotype terms, read definitions and explore the phenotype hierarchy - keyless.

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Quickgo MCP
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Gene Ontology terms, definitions, hierarchy and protein annotations via EBI QuickGO - keyless.

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MCP Books
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Search the Internet Archive, the Library of Congress and data.bnf.fr at once, in one answer.

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Monadomain MCP
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Buy .vn and international domains in VND from the terminal; search and reserve without an account

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Interpro MCP — questions

Answers built from our own checks of this server.

Why is there no uptime for Interpro MCP?
Interpro MCP runs on your own machine over stdio — there is no network address to reach, so uptime cannot be measured for it by anyone. What can be measured is adoption: the npm package @mrfentmen/interpro-mcp was installed 122 times last week.
How do I connect Interpro MCP?
Copy the ready config from this page. We generate it for Claude Code, Claude Desktop, Codex, Cursor and VS Code, each in the form that client actually reads. It runs locally, so the command pulls @mrfentmen/interpro-mcp straight from npm; nothing to host, nothing to sign up for.
How many people use Interpro MCP?
The npm package @mrfentmen/interpro-mcp was installed 122 times in the last week. Week over week that is -83%. We show installs rather than GitHub stars on purpose: a star is a bookmark, an install is someone actually running it.
Is Interpro MCP open source?
We cannot say either way: written in TypeScript and 0 stars on GitHub, but we could not determine the licence, and without one the code is not open source by default.