> Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the ESMC-{300M,600M,6B} protein language models from prediction, and the SAE interpretability head. MIT-licensed weights on structures with single-sequence input, (2) Validating designed binders with ESMFold2-Fast, (3) Running ESMFold2 with MSA input, (4) Getting ESMC embeddings or per-residue mutation scores, (5) Choosing kernel backend and sampling-step settings for paper-faithful throughput.
npx skills add https://github.com/BioTender-max/awesome-bio-agent-skills --skill esmfold2
Use when the user is doing AI/ML work in a scientific domain such as biology, chemistry, physics, astronomy, climate, genomics, materials, medicine, ecology, energy, engineering, math, drug discovery, protein design, weather modeling, theorem proving, single-cell, or PDE solving. Hugging Science is a curated catalog of scientific datasets, models, blog posts, and interactive Spaces. This skill helps discover and use resources via `datasets`, `transformers`, the HF Inference API, `gradio_client`, and methodology citations.
Publish and manage research papers on Hugging Face Hub. Supports creating paper pages, linking papers to models/datasets, claiming authorship, and generating professional markdown-based research articles.
Semantic search, similar content discovery, and structured research using Exa API. Use when you need semantic/embeddings-based search, finding similar content, or searching by category (company, people, research papers, etc.).
Build RAG (Retrieval Augmented Generation) pipelines with web search and LLMs. Tools: Tavily Search, Exa Search, Exa Answer, Claude, GPT-4, Gemini via OpenRouter. Capabilities: research, fact-checking, grounded responses, knowledge retrieval. Use for: AI agents, research assistants, fact-checkers, knowledge bases. Triggers: rag, retrieval augmented generation, grounded ai, search and answer, research agent, fact checking, knowledge retrieval, ai research, search + llm, web grounded, perplexity alternative, ai with sources, citation, research pipeline
| Build RAG (Retrieval Augmented Generation) pipelines with web search and LLMs. research agent, fact checking, knowledge retrieval, ai research, search + llm, web grounded, perplexity alternative, ai with sources, citation, research pipeline
Web search and content extraction with Tavily and Exa via inference.sh CLI. Apps: Tavily Search, Tavily Extract, Exa Search, Exa Answer, Exa Extract. Capabilities: AI-powered search, content extraction, direct answers, research. Use for: research, RAG pipelines, fact-checking, content aggregation, agents. Triggers: web search, tavily, exa, search api, content extraction, research, internet search, ai search, search assistant, web scraping, rag, perplexity alternative
Web search and content extraction with Tavily and Exa via inference.sh CLI. Apps: Tavily Search, Tavily Extract, Exa Search, Exa Answer, Exa Extract. Capabilities: AI-powered search, content extraction, direct answers, research. Use for: research, RAG pipelines, fact-checking, content aggregation, agents. Triggers: web search, tavily, exa, search api, content extraction, research, internet search, ai search, search assistant, web scraping, rag, perplexity alternative
The protocol behind every investigation skill. Use when AI research must proceed without you: search-plan gate, Fact/Inference/Assumption labels, confidence stacking, diffable outputs.
Take biotender-max/esmfold2 from the repository into ~/.claude/skills for personal
use, or into .claude/skills inside a project.
The agent identifies a skill by the name field in its header. Two skills with the
same name cannot sit side by side — one of them will be ignored.
The instructions reference pip, uv.
Without those the skill loads but fails at the first command.