Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
npx skills add https://github.com/BioTender-max/awesome-bio-agent-skills --skill bio-clinical-databases-somatic-signatures
Expert database architect specializing in data layer design from scratch, technology selection, schema modeling, and scalable database architectures. Masters SQL/NoSQL/TimeSeries database selection, normalization strategies, migration planning, and performance-first design. Handles both greenfield architectures and re-architecture of existing systems. Use PROACTIVELY for database architecture, technology selection, or data modeling decisions.
>- Configures GKE Backup Plans and restore workflows. Use for backup policies, disaster recovery, or GKE cluster restores. Don't use for database backups.
Creates explicit validation checkpoints (verification gates) between project phases to catch errors early and ensure quality before proceeding. Use when the user asks about quality gates, milestone checks, phase transitions, approval steps, go/no-go decision points, or preventing cascading errors across a multi-step workflow. Produces acceptance criteria checklists, automated CI gate configurations, manual sign-off requirements, and conditional review rules for scenarios such as security changes, API changes, or database migrations.
Unified CloudBase execution guide for all-in-one skill installs. Use this first for CloudBase app tasks, especially existing apps with TODOs, fixed pages, or active handlers. Routes PostgreSQL / CloudBase PG / app.rdb() / queryPgDatabase / managePgDatabase work away from legacy NoSQL and old auth patterns.
Implement, review, or improve data persistence using SwiftData. Use when defining @Model classes with @Attribute, @Relationship, @Transient, #Unique, or #Index; when querying with @Query, #Predicate, FetchDescriptor, or SortDescriptor; when configuring ModelContainer and ModelContext for SwiftUI or background work with @ModelActor; when planning schema migrations with VersionedSchema and SchemaMigrationPlan; when setting up CloudKit sync with ModelConfiguration; or when coexisting with or migrating from Core Data.
Plan and run backups, set recovery objectives, and run disaster recovery drills. Use this skill when defining RPO/RTO targets, designing backup architecture, deciding what to back up and how often, planning for full-region or platform outages, or running a restoration drill. Triggers on backup, restore, RPO, RTO, disaster recovery, DR, business continuity, what if the database is gone, what if our hosting goes down, recovery drill, ransomware planning. Also triggers when an incident reveals a gap in restoration capability.
Expert database architect specializing in data layer design from scratch, technology selection, schema modeling, and scalable database architectures. Masters SQL/NoSQL/TimeSeries database selection, normalization strategies, migration planning, and performance-first design. Handles both greenfield architectures and re-architecture of existing systems. Use PROACTIVELY for database architecture, technology selection, or data modeling decisions.
> System architecture design and review. Use when designing architecture, evaluating microservices vs monolith, writing ADRs, choosing a database, planning for scalability, reviewing system design, or generating architecture diagrams.
Take biotender-max/bio-clinical-databases-somatic-signatures from the repository into ~/.claude/skills for personal
use, or into .claude/skills inside a project.
The agent identifies a skill by the name field in its header. Two skills with the
same name cannot sit side by side — one of them will be ignored.