Can Immune MCP Server

by sanjaysgk Your server? Claim it

answering

Can Immune is answering right now. Last checked 5 min ago. It exposes 12 tools. Last commit 10 Aug 2026.

Query CAN-IMMUNE: cancer neoantigen mutations, peptides, cell lines, MHC-I binding. Read-only.

Uptime history 91 days of history · worst day 89%

91 days agonow

100.0%

Uptime 24h

91 of 91 checks

Tools

read from the server

1140 ms

Response time

average over 24h

Stars

last commit 10 Aug 2026

Nothing serious here today

Today is the operative word: we check Can Immune every 15 minutes and re-read its code on every release. Watch it and you find out the day that stops being true.

Connect this server

Endpoint below is the one we actually reach during checks — not the one copied from a README. Last verified 5 min ago.

Claude Code Claude Desktop Codex Cursor VS Code

run in your terminal

claude mcp add can-immune --transport http https://canelib.erc.monash.edu/mcp

Settings → Connectors → Add custom connector, then paste this address

https://canelib.erc.monash.edu/mcp

~/.codex/config.toml

[mcp_servers.can-immune]
url = "https://canelib.erc.monash.edu/mcp"

.cursor/mcp.json

{
  "mcpServers": {
    "can-immune": {
      "url": "https://canelib.erc.monash.edu/mcp"
    }
  }
}

.vscode/mcp.json

{
  "servers": {
    "can-immune": {
      "type": "http",
      "url": "https://canelib.erc.monash.edu/mcp"
    }
  }
}

Available tools 12

Read directly from the server with tools/list, grouped by what they act on. If a tool disappears, we record the date.

cell

get_cell_line

Get the full profile for one cancer cell line by exact name. Returns tissue of origin, cancer type, total mutations, unique mutant peptides and genes, data sources, Cellosaurus and DepMap model IDs, gender, category / cell type, and the top ~15 most-mutated genes in that line, plus a link to its page. Use after `search_cell_lines`, or when the exact name is known, for a deep dive on one line. Returns an error field if the name is not found.

search_cell_lines

Find cancer cell lines by name, ranked by mutation burden. Returns each matching cell line with its tissue of origin, cancer type, total mutations, unique mutant peptides, data sources (COSMIC / DepMap-CCLE / PubMed), and Cellosaurus ID. Covers only cell-line models (kept separate from primary tissue samples). Use before `get_cell_line` or `top_genes_in_cell_line`. Ordered by mutation count (most mutated first).

gene

get_gene

Get the full profile for one gene by exact symbol. Returns total mutations and how they split between cell lines vs tissues, unique mutant peptides, sample and transcript counts, UniProt accession / name / reviewed status, the top ~15 recurrent mutations in that gene, and a link to the gene page. Use this after `search_genes` (or when you already know the symbol) to answer detailed questions about a single gene. Returns an error field if the symbol is not found.

get_gene_mutations

List individual mutations in a gene (a bounded sample of rows). Each row gives the CAN-IMMUNE mutation ID (CANLIB...), the amino-acid change, the CDS change, mutation type (missense / complex substitution), data source, the sample it came from, its primary site, and the mutant peptide. Ordered by mutation ID. Capped at `limit` rows (max 100) for speed - for the complete table of a heavily-mutated gene, link the user to the gene page on the website.

cancer

list_cancer_types

List cancer types (histology) ranked by mutation burden. Returns each cancer type / histology with its total mutations, unique samples, and unique genes, most-mutated first. Use to see which cancer types dominate the database or to pick one for further drill-down on the website.

database

database_overview

Get the headline size of the CAN-IMMUNE database in one call. Returns total counts of mutations, genes, and unique mutant peptides, plus how many cell lines, tissues, and cancer types are covered, and the data sources (COSMIC, DepMap/CCLE, PubMed). Use this first to size the resource or to answer "how big is the database / how many X are there" questions. No parameters.

fetch

fetch

Fetch the full record for an id returned by `search` (ChatGPT connector interface). Takes an id like 'gene:TP53' or 'cell_line:MDA-MB-231' and returns {id, title, text, url, metadata} where `text` is the full JSON profile (same data as get_gene / get_cell_line). Always call `search` first to obtain a valid id.

genes

search_genes

Find genes by symbol or full name, ranked by how mutated they are. Matches the gene symbol OR the full gene name (partial, case-insensitive) and returns each hit with its total mutation count, unique mutant-peptide count, sample count, and UniProt accession. Use it to locate a gene before calling `get_gene`, or to rank a set of genes by mutation burden. Results are ordered by mutation count (most mutated first).

mhc

get_mhc_binding

Look up a CACHED MHC-I binding prediction for a peptide + HLA allele. Returns the NetMHCpan result (best binding core, %Rank_EL, binder level SB/WB/NB, and neoepitope %Rank_Neo when computed) for predictions already stored in the cache. This tool does NOT run new predictions - it only reads cached ones; if nothing is cached it returns cached=false with a note. To generate a new prediction, use the interactive button on the mutation page of the website.

search

Search CAN-IMMUNE for genes and cell lines (ChatGPT connector interface). Returns {results: [{id, title, url}]} combining matching genes and cell lines, each with a stable `id` (like 'gene:TP53' or 'cell_line:MDA-MB-231'). Pass that `id` to `fetch` to retrieve the full record. This is the generic search endpoint ChatGPT expects; MCP-native clients can also use the more specific `search_genes` / `search_cell_lines` tools.

tissues

list_tissues

List primary tissues ranked by mutation burden. Returns each tissue (COSMIC primary-tissue samples only, kept separate from cell lines) with its total mutations, unique samples, and unique genes, most-mutated first. Use for tissue-level questions; for cell lines use `search_cell_lines`.

top

top_genes_in_cell_line

Rank the most-mutated genes within one specific cell line. Answers "what is the top mutated gene in <cell line>" / "which genes are most altered in <cell line>". Returns genes with their mutation counts for that line, highest first, from precomputed per-cell-line stats (fast). For the whole profile of the line use `get_cell_line` instead.

Endpoints

URL	Transport	State	Latency	Checked
https://canelib.erc.monash.edu/mcp	streamable-http	answering	1407 ms	5 min ago

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Can Immune — questions

Answers built from our own checks of this server.

What can Can Immune do?

It exposes 12 tools, read directly from the server on our last check. Among them: database_overview, fetch, get_cell_line, get_gene, get_gene_mutations, get_mhc_binding and 6 more. The full list with descriptions is on this page — we take it from the server itself via tools/list, not from a README. How MCP servers expose tools in the first place →

What is Can Immune mostly used for?

Its tools cluster around cell and gene. That is what this server is built to work with — the grouping comes from the actual tool names, not from a category we assigned.

Is Can Immune working right now?

We send a real MCP handshake every 15 minutes. Over the last 24 hours 91 of 91 checks got a reply (100.0%), average response time 1140 ms. The bar chart above shows every period we have measured.

How do I connect Can Immune?

Copy the ready config from this page. We generate it for Claude Code, Claude Desktop, Codex, Cursor and VS Code, each in the form that client actually reads. It is a remote server, so there is nothing to install — the client connects to the address.

Does Can Immune need an API key?

No. Can Immune completed a full MCP handshake with us as an anonymous client and listed its tools without asking for anything. All 12 of them are readable on this page. This is what we observed, not what the docs claim.

How fast is Can Immune?

It answers our handshake in 1140 ms on average, which is faster than 5% of all working MCP servers we measure. That is on the slow side — worth knowing if the tool sits inside an interactive loop. The comparison comes from our own checks across the whole registry, every 15 minutes.

Is Can Immune open source?

The code is open source: it is published under the MIT licence, written in Python and 0 stars on GitHub. The licence covers the code in the repository, not the hosted service at canelib.erc.monash.edu, which runs on its operator's own terms.