Cosmetic Regulatory MCP Server

Calculate Margin of Safety for a cosmetic ingredient at a specific concentration following SCCS Notes of Guidance methodology. Input: ingredient name/INCI/CAS, concentration percentage, product type (e.g. 'body lotion', 'shampoo', 'lipstick'), optional body weight and dermal absorption override. Returns: NOAEL value with study source (species, route, duration), SCCS exposure parameters (daily exposure, retention factor), Systemic Exposure Dose (SED) calculation, Margin of Safety value, pass/fail assessment against MoS>100 threshold, and recommended maximum concentration if MoS fails. Sources: SCCS Notes of Guidance (11th Revision, SCCS/1628/21), NOAEL studies from ECHA/ToxValDB, SCCS exposure parameter tables. Database: 174,973 NOAEL studies searched for best available value. Use for cosmetic ingredient exposure assessment and safety calculations. Do not use for regulatory lookup alone (use check_ingredient), formula screening (use check_formula), or food/pharmaceutical exposure calculations.

Scan a cosmetic product INCI ingredient list for regulatory compliance and safety flags across multiple jurisdictions. Input: comma-separated INCI declaration as printed on a cosmetic product label (up to 50 ingredients). Returns per-ingredient: matched INCI name, CAS number, safety rating, EU and US regulatory status, concern level, regulatory flags, NOAEL values, and jurisdiction-specific restrictions including max concentration limits, product-type restrictions, and regulation references. Returns overall: LOW/MODERATE/HIGH formula risk assessment, flagged ingredient count with reasons, and jurisdiction-level compliance summary. Sources: EU Regulation 1223/2009, US FDA, Korea MFDS, Japan MHLW, ASEAN, Saudi SFDA, Canada Hotlist, Australia SUSMP, China IECIC. Database: 30,553 cosmetic ingredients across 55+ jurisdictions. Use for cosmetic formula safety screening and CPSR-style triage. Do not use for single ingredient lookup (use check_ingredient) or custom MoS calculations (use calculate_mos).

Retrieve cosmetic ingredient safety data for regulatory compliance and safety assessment. Input: common name, INCI name, or CAS number (e.g. 'retinol', 'RETINOL', '68-26-8'). Returns: NOAEL study values with species/route/duration, pre-calculated Margin of Safety from SCCS opinions, GHS hazard classifications, EU/US/Korea/Japan/ASEAN/Saudi/Canada/Australia regulatory status across 12 jurisdictions, SCCS opinion summaries, CIR safety conclusions, dermal absorption profiles, sensitization data with patch-test frequencies, endocrine disruption flags, SVHC status, IFRA fragrance restrictions, China IECIC listing, and EU allergen classifications. Sources include ECHA IUCLID dossiers, SCCS opinions, CIR safety assessments, FDA, ToxValDB, and EPA CompTox. Database: 30,553 cosmetic ingredients, 174,973 NOAEL studies, 8,898 sensitization assays, 5,267 CIR safety conclusions, and 1,583 SCCS opinions. Use for cosmetic ingredient safety assessment. Do not use for full formula scans (use check_formula), MoS calculations with custom concentration (use calculate_mos), food additive questions, or pharmaceutical actives.

Search cosmetic ingredient records by partial name, function, category, or safety concept for ingredient discovery and selection. Input: keyword matching partial INCI name, function, or category (e.g. 'sunscreen', 'preservative', 'retinoid', 'fragrance allergen', 'humectant'). Returns: matching cosmetic ingredient names, INCI names, CAS numbers, functions/categories, safety ratings, EU regulatory status, concern levels, and NOAEL availability. Database: 30,553 cosmetic ingredients with safety profiles. Use for cosmetic ingredient discovery before checking a specific ingredient. Do not use when the user has an exact INCI/CAS and needs full safety data (use check_ingredient).