Folklore Clinical Variant Interpretation MCP Server

by helena-bioinformatics

answering

Folklore Clinical Variant Interpretation MCP is answering right now. Last checked 14 min ago. It exposes 3 tools.

Helena Bioinformatics MCP for clinical variant interpretation, ACMG/AMP evidence and literature.

Uptime history 4 days of history · worst day 99%

4 days agonow

98.9%

Uptime 24h

90 of 91 checks

Tools

read from the server

48 ms

Response time

average over 24h

open, no key

Access

streamable-http

Connect this server

Endpoint below is the one we actually reach during checks — not the one copied from a README. Last verified 14 min ago.

Claude Code Claude Desktop Codex Cursor VS Code

run in your terminal

claude mcp add folklore --transport http https://api.helena.bio/folklore/v1/mcp

~/Library/Application Support/Claude/claude_desktop_config.json

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

~/.codex/config.toml

[mcp_servers.folklore]
url = "https://api.helena.bio/folklore/v1/mcp"

.cursor/mcp.json

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

.vscode/mcp.json

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

Available tools 3

Read directly from the server with tools/list, grouped by what they act on. If a tool disappears, we record the date.

variant

search_variant_evidence

Classify, interpret or resolve one public GRCh38 germline SNV or simple indel smaller than 50 bp. Accepts coordinates, genomic/coding/protein HGVS, SPDI or rsID. Returns normalized variant identity, automated ACMG/AMP decision support, evidence, provenance and explicit limitations. This is variant-level decision support for professional review. It does not evaluate patient context and must not be presented as a diagnosis or treatment recommendation. Never choose a candidate when resolution is ambiguous.

search_variant_literature

Resolve one public GRCh38 germline variant and retrieve relevant publications from Folklore's PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Use when a user asks what has been published about a variant, gene or associated condition. Associations do not establish causality, pathogenicity or a diagnosis and do not change Folklore's ACMG/AMP classification.

publication

get_publication_details

Retrieve the complete public bibliographic record for one PMID from Folklore's PubMed-derived genetics corpus. Returns the full abstract, authors, journal metadata, publication and MeSH terms, gene and variant mentions, retraction status, and PubMed/PMC links. Use after literature search when a user asks to inspect a specific publication. This is read-only professional literature evidence and contains no patient context.

Endpoints

URL	Transport	State	Latency	Checked
https://api.helena.bio/folklore/v1/mcp	streamable-http	answering	69 ms	14 min ago

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Folklore Clinical Variant Interpretation MCP — questions

Answers built from our own checks of this server.

What can Folklore Clinical Variant Interpretation MCP do?

It exposes 3 tools, read directly from the server on our last check. Among them: get_publication_details, search_variant_evidence, search_variant_literature. The full list with descriptions is on this page — we take it from the server itself via tools/list, not from a README. How MCP servers expose tools in the first place →

Is Folklore Clinical Variant Interpretation MCP working right now?

We send a real MCP handshake every 15 minutes. Over the last 24 hours 90 of 91 checks got a reply (98.9%), average response time 48 ms. The bar chart above shows every period we have measured.

How do I connect Folklore Clinical Variant Interpretation MCP?

Copy the ready config from this page — we generate it for Claude Code, Claude Desktop, Codex, Cursor and VS Code, each with the file path that client actually reads. It is a remote server, so there is nothing to install — the client connects to the address.

Does Folklore Clinical Variant Interpretation MCP need an API key?

No. Folklore Clinical Variant Interpretation MCP completed a full MCP handshake with us as an anonymous client and listed its tools without asking for anything. All 3 of them are readable on this page. This is what we observed, not what the docs claim.

How fast is Folklore Clinical Variant Interpretation MCP?

It answers our handshake in 48 ms on average, which is faster than 98% of all working MCP servers we measure. That puts it in the quick quarter of the ecosystem. The comparison comes from our own checks across the whole registry, every 15 minutes.