Pubchem MCP Server is answering right now. Last checked 1 min ago. 495 installs a week from npm. It exposes 10 tools. Last commit 14 Sep 2026.
Search PubChem compounds, properties, safety data, bioactivity, and cross-references.
Every tool that appeared, vanished or quietly changed what it asks for. Recorded since 22 August 2026. No other catalogue keeps this.
Today is the operative word: we check Pubchem MCP Server every 15 minutes and re-read its code on every release. Watch it and you find out the day that stops being true.
Endpoint below is the one we actually reach during checks — not the one copied from a README. Last verified 1 min ago.
claude mcp add pubchem-mcp-server --transport http https://pubchem.caseyjhand.com/mcp
{
"mcpServers": {
"pubchem-mcp-server": {
"url": "https://pubchem.caseyjhand.com/mcp"
}
}
}
[mcp_servers.pubchem-mcp-server]
url = "https://pubchem.caseyjhand.com/mcp"
{
"mcpServers": {
"pubchem-mcp-server": {
"url": "https://pubchem.caseyjhand.com/mcp"
}
}
}
{
"mcpServers": {
"pubchem-mcp-server": {
"url": "https://pubchem.caseyjhand.com/mcp"
}
}
}
This one needs environment variables set before it will start:
MCP_SESSION_MODE (HTTP session mode: stateless, stateful, or auto. Stateless is sufficient for PubChem; auto resolves to stateful.), MCP_HTTP_HOST (The hostname for the HTTP server.), MCP_HTTP_PORT (The port to run the HTTP server on.), MCP_HTTP_ENDPOINT_PATH (The endpoint path for the MCP server.), MCP_AUTH_MODE (Authentication mode to use: 'none', 'jwt', or 'oauth'.), MCP_LOG_LEVEL (Sets the minimum log level for output (e.g., 'debug', 'info', 'warn').).
The author declared them in the registry entry; get the values from the project itself.
Read directly from the server with tools/list, grouped by what they act on.
If a tool disappears, we record the date.
pubchem_get_bioactivity
pubchem_get_compound_3d_structure
pubchem_get_compound_details
pubchem_get_compound_image
pubchem_get_compound_interactions
pubchem_get_compound_safety
pubchem_get_compound_xrefs
pubchem_get_summary
pubchem_search_assays
pubchem_search_compounds
| URL | Transport | State | Latency | Checked |
|---|---|---|---|---|
| https://pubchem.caseyjhand.com/mcp | streamable-http | answering | 399 ms | 1 min ago |
MCP server to search, inspect, and cross-reference RCSB Protein Data Bank structures
Search properties via Redfin and Google Maps real estate data
Search & compare prices for tours, activities and tickets across multiple providers.
Search UK companies, land registry prices, charities, OS locations, and traffic data
Search Checkout.com docs and API reference, plus manage payments, refunds, and payment links.
Search Redfin properties, get property details, and market statistics
Search and compare concert ticket prices across platforms
Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.
Answers built from our own checks of this server.