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Rosetta MCP Server

local only

Rosetta MCP Server runs on your own machine — the client starts it, so there is no endpoint to ping. 97 installs a week from npm. Last commit 5 Apr 2026.

Rosetta/PyRosetta protein modeling and Biotite translation for computational biology

Installs per day peak 897 · avg 84 · -90% w/w
a month agotoday
97
Installs / week
npm · rosetta-mcp-server
19
Stars
2 open issues
5 Apr 2026
Last commit
0 releases in 90 days
MIT
License
JavaScript

What the code does

We read the source, 23 min ago · rules 3dff92dd89df

A tool parameter reaches a dangerous call

A value the model can set ends up inside a file or shell call. That is not a flaw by itself — for a terminal server it is the job — but it is where things go wrong when it is not.

A tool parameter reaches a dangerous call search_rosetta_web_docs.max_results → rosetta_mcp_wrapper.js:1232, translate_rosetta_script_to_biotite.max_results → rosetta_mcp_wrapper.js:1232
            const proc = spawn(py, ['-c', script], {
Capabilities

What this server is able to do. For an MCP server this is often the job itself — a terminal server runs commands because that is what it is for. Listed so you know what you are plugging in, not as an accusation.

            const proc = spawn(py, ['-c', script]);
                    if (match) return path.join(p, match);
Long encoded blob in source rosetta_mcp_http.js:261
        const iconB64 = 'iVBORw0KGgoAAAANSUhEUgAAAgAAAAIACAYAAAD0eNT6AAAJcUlEQVR4nO3YsW3jWhRFUfqDVQiMVYg6UBkMVIIil8BAZbgDFuJ4MLkTB078u5gb7LUaeAeUDWzct5/vr98FAEj5b3oAAPDvCQAACBIAABAkAAAgSAAAQJAAAIAgAQAAQQIAAIIEAAAECQAACBIAABAkAAAgSAAAQJAAAIAgAQAAQQIAAIIEAAAECQAACBIAABAkAAAgSAAAQJA…

Is this your server and something here is wrong? Tell us — corrections are free and do not require a plan.

A tool parameter here reaches a dangerous call

That is not a flaw by itself — but it is where things go wrong when it is not the job. We re-read this code on every release. Watch it and you hear from us the day another one appears.

Three servers free · no card

Connect this server

This server runs on your own machine — install it with the package manager and the client starts it for you. Package name taken from the official registry entry.

run in your terminal
claude mcp add rosetta-mcp-server -- npx -y rosetta-mcp-server
~/Library/Application Support/Claude/claude_desktop_config.json
{
  "mcpServers": {
    "rosetta-mcp-server": {
      "args": [
        "-y",
        "rosetta-mcp-server"
      ],
      "command": "npx"
    }
  }
}
~/.codex/config.toml
[mcp_servers.rosetta-mcp-server]
command = "npx"
args = ["-y", "rosetta-mcp-server"]
.cursor/mcp.json
{
  "mcpServers": {
    "rosetta-mcp-server": {
      "args": [
        "-y",
        "rosetta-mcp-server"
      ],
      "command": "npx"
    }
  }
}
.vscode/mcp.json
{
  "mcpServers": {
    "rosetta-mcp-server": {
      "args": [
        "-y",
        "rosetta-mcp-server"
      ],
      "command": "npx"
    }
  }
}

This one needs environment variables set before it will start: ROSETTA_BIN (Path to rosetta_scripts binary or its directory), PYTHON_BIN (Python interpreter with PyRosetta/Biotite installed), MCP_DEBUG (Set to 1 for debug logging). The author declared them in the registry entry; get the values from the project itself.

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Rosetta MCP Server — questions

Answers built from our own checks of this server.

Why is there no uptime for Rosetta MCP Server?
Rosetta MCP Server runs on your own machine over stdio — there is no network address to reach, so uptime cannot be measured for it by anyone. What can be measured is adoption: the npm package rosetta-mcp-server was installed 97 times last week.
How do I connect Rosetta MCP Server?
Copy the ready config from this page — we generate it for Claude Code, Claude Desktop, Codex, Cursor and VS Code, each with the file path that client actually reads. It runs locally, so the command pulls rosetta-mcp-server straight from npm; nothing to host, nothing to sign up for.
How many people use Rosetta MCP Server?
The npm package rosetta-mcp-server was installed 97 times in the last week. Week over week that is -90%. We show installs rather than GitHub stars on purpose: a star is a bookmark, an install is someone actually running it.
Is Rosetta MCP Server open source?
Yes — it is published under the MIT licence, written in JavaScript, 19 stars on GitHub and 2 open issues. The source link is on this page, so you can read exactly what it does with your data before you connect it.