Rosetta MCP Server runs on your own machine — the client starts it, so there is no endpoint to ping. 97 installs a week from npm. Last commit 5 Apr 2026.
Rosetta/PyRosetta protein modeling and Biotite translation for computational biology
We read the source, 23 min ago · rules 3dff92dd89df
A value the model can set ends up inside a file or shell call. That is not a flaw by itself — for a terminal server it is the job — but it is where things go wrong when it is not.
const proc = spawn(py, ['-c', script], {
What this server is able to do. For an MCP server this is often the job itself — a terminal server runs commands because that is what it is for. Listed so you know what you are plugging in, not as an accusation.
const proc = spawn(py, ['-c', script]);
if (match) return path.join(p, match);
const iconB64 = 'iVBORw0KGgoAAAANSUhEUgAAAgAAAAIACAYAAAD0eNT6AAAJcUlEQVR4nO3YsW3jWhRFUfqDVQiMVYg6UBkMVIIil8BAZbgDFuJ4MLkTB078u5gb7LUaeAeUDWzct5/vr98FAEj5b3oAAPDvCQAACBIAABAkAAAgSAAAQJAAAIAgAQAAQQIAAIIEAAAECQAACBIAABAkAAAgSAAAQJAAAIAgAQAAQQIAAIIEAAAECQAACBIAABAkAAAgSAAAQJA…
Is this your server and something here is wrong? Tell us — corrections are free and do not require a plan.
That is not a flaw by itself — but it is where things go wrong when it is not the job. We re-read this code on every release. Watch it and you hear from us the day another one appears.
This server runs on your own machine — install it with the package manager and the client starts it for you. Package name taken from the official registry entry.
claude mcp add rosetta-mcp-server -- npx -y rosetta-mcp-server
{
"mcpServers": {
"rosetta-mcp-server": {
"args": [
"-y",
"rosetta-mcp-server"
],
"command": "npx"
}
}
}
[mcp_servers.rosetta-mcp-server]
command = "npx"
args = ["-y", "rosetta-mcp-server"]
{
"mcpServers": {
"rosetta-mcp-server": {
"args": [
"-y",
"rosetta-mcp-server"
],
"command": "npx"
}
}
}
{
"mcpServers": {
"rosetta-mcp-server": {
"args": [
"-y",
"rosetta-mcp-server"
],
"command": "npx"
}
}
}
This one needs environment variables set before it will start:
ROSETTA_BIN (Path to rosetta_scripts binary or its directory), PYTHON_BIN (Python interpreter with PyRosetta/Biotite installed), MCP_DEBUG (Set to 1 for debug logging).
The author declared them in the registry entry; get the values from the project itself.
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Answers built from our own checks of this server.